TYPES AND DISTRIBUTION OF PROSTATE DISEASE IN ASYMPTOMATIC PATIENTS: A PROSPECTIVE POST-MORTEM STUDY FROM UNIVERSITY COLLEGE HOSPITAL, IBADAN

Abstract

This prospective study was undertaken to ascertain the incidence, frequency, histology and
pathological features of different types of asymptomatic or sub clinical prostatic diseases.
Prostate glands were obtained from 79 individuals who died from non-prostate related diseases at
the University College Hospital Ibadan between February 3, 2010 and November 12, 2011. The
glands were weighed and fixed in 10% neutral buffered formalin. The sampling method of the
prostate gland described by Bostwick and Meiers (2009) was employed in this study. Paraffin
embedded sections were stained with haematoxylin and eosin and were systematically examined
for focal prostate disease.
The patients’ ages ranged from 30 to 86 years. The most common lesions were nodular
hyperplasia (81%), and adenocarcinoma (6.3%). Three cases (3.8%) had schistosomiasis.
Adenocarcinoma and nodular hyperplasia occurred in relatively older patients than those with
normal glands or chronic prostatitis/schistosomiasis (p = 0.05). There was an increase in the
weight of prostate with age (p < 0.001) and normal prostate glands weighed significantly less
than diseased glands (p = 0.02).Focal prostatic atrophy was observed in 24.1% and metaplastic
changes were observed in eight (10.1%) of the cases.
The low frequency of prostatic adenocarcinoma and the absence of high grade prostatic
intraepithelial neoplasia in this study and a previous study from Lagos, Nigeria despite the
observation of increasing number of prostatic carcinoma require further investigation.
Schistosomiasis was also found to be present in the adult male population.