Prof.Antia-Obong gained admission into the Medical School, University of Ibadan in 1969 and obtained the Bachelor of Medicine and Surgery (MB,BS) degree in 1975.

In 1977, he started residency training in Paediatrics at the University College Hospital, Ibadan. During the residency he spent a year (1983-1984) as a research registrar at the Royal Hospital for Sick Children, Yorkhill, Glasgow, Scotland. He became a Fellow of the National Postgraduate Medical College of Nigeria in the Faculty of Paediatrics in 1985.

In December, 1985 he was appointed a lecturer1 in the College of Medical Sciences, University of Calabar and a Consultant Pediatrician to the University of Calabar and rose the rank of Professor of Paediatrics in 2000.

He was acting Head, Deptment of Paediatics, College of Medical Sciences, University of Calabar Teaching Hospital (1991-1993).

He is a former Acting Dean, Faculty of Clinical sciences, College of Medical Science University of Calabar, (October 2004-February 2005). He has been an active member of the Medical and Dental Consultants Association, University of Calabar Teaching Hospital where he served as Financial Secretary and later as the chairman from (2002-2004). He was the 2nd National Vice-President of the Medical and Dental Consultants Association of Nigeria (2003-2005). Prof. Antia-Obong is a teacher with several published works.

He is happily married with children. He assumed duty as College Registrar on 1st march, 2005.